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患有类风湿性关节炎的绝经后妇女中与萨尔科佩尼亚相关的患病率和因素
Dimitra Moschou1, Michail Krikelis1, Christos Georgakopoulos1
1Rheumatology Department, KAT General Hospital, Attica, Greece.
Mediterranean journal of rheumatology
|October 28, 2024
概括
麻症在患有类风湿性关节炎 (RA) 的绝经后妇女中更为普遍. 与非sarcopenic个体相比,sarcopenic的RA患者表现出较低的体重指数,身体活动,肌肉质量和手握强度.
科学领域:
- 类风湿病学 类风湿病学
- 老年学是指老年学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性疾病,影响关节.
- 绝经后的女性患上肉症的风险增加,这种疾病的特征是肌肉质量和力量的损失.
- 在患有RA的绝经后妇女中,肉类的患病率和特征尚不清楚.
研究的目的:
- 为了确定被诊断为RA的绝经后妇女中肉类的患病率.
- 探索RA患者的萨尔科佩尼亚和疾病参数之间的潜在相关性.
主要方法:
- 一项涉及80名患有RA的绝经后妇女和30名对照者的横截面研究.
- 基于EWGSOP-II标准进行的肉症评估;骨质疏松症以骨矿物质密度来定义.
- 评估RA疾病活动 (DAS28-ESR),炎症标志物 (ESR,CRP),功能 (HAQ-DI) 和血清阳性 (RF,抗CCP).
主要成果:
- 39%的RA患者符合肉症的标准,对照组为0% (p<0.0001).
- 麻性RA患者的BMI,体力活动 (IPAQ),骨肌量 (ASMI) 和手握强度显著降低.
- 在萨科佩尼性和非萨科佩尼性RA患者之间,没有发现RA疾病参数或骨周转标记的显著差异. 胰岛素样生长因子1 (IGF-1) 在肉患者中较低 (p=0.024).
结论:
- 肉症在患有RA的绝经后妇女中明显更为常见.
- 较低的体力活动,肌肉质量和力量是萨科佩尼性RA患者的特征.
- IGF-1 可能是一个相关的生物标志物,可以区分肉性RA患者.
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