生殖毒理学:跟上我们不断变化的世界
Laura B Miller1, Morgan B Feuz1, Ralph G Meyer1
1Department of Veterinary, Clinical and Life Sciences, College of Veterinary Medicine, Utah State University, Logan, UT, United States.
Frontiers in toxicology
|October 28, 2024
概括
生殖毒理学测试必须不断发展,以应对新的风险,如内分泌干扰物和代际影响. 需要现代方法,包括先进的体外和体内方法,以全面评估男性生殖健康.
科学领域:
- 生殖毒理学和公共卫生.
背景情况:
- 传统的生殖毒理学侧重于急性毒性和不孕症.
- 新出现的担忧包括内分泌干扰物和对后代的代际健康影响.
- 人口变化,如增加的父亲年龄和肥胖症,需要更新的测试设计.
研究的目的:
- 为了突出目前生殖毒理学测试协议的局限性.
- 倡导扩大生殖终点,包括遗传和表观遗传精子参数.
- 讨论新方法在生殖毒理学的潜力.
主要方法:
- 审查目前的生殖毒理学测试限制.
- 探索人类生殖的新兴趋势 (父亲的年龄,肥胖).
- 讨论先进的测试策略:混合物测试,新型动物模型,体外系统 (有机体),多代协议,in silico建模,机器学习和AI.
主要成果:
- 标准协议在表示当前人口特征和暴露情况方面存在局限性.
- 不良结果超越不孕不育,包括代谢,神经发育和后代的癌症风险.
- 遗传和表观遗传性精子参数至关重要,未充分利用的终点.
结论:
- 生殖毒理学测试需要进行重大更新,以解决复杂的,代际影响和不断变化的人口动态.
- 整合先进的技术,如有机体,人工智能和in silico建模,对于全面的风险评估至关重要.
- 未来的测试必须包含遗传和表观遗传因素,以准确评估生殖毒素.
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