内在动态塑造了人类大脑对外部刺激的反应
Maximilian Nentwich1, Marcin Leszczynski2,3,4, Charles E Schroeder2,3
1The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
bioRxiv : the preprint server for biology
|October 28, 2024
概括
新的大脑模型显示,大脑的内在动力学显著增强和延长神经对感官输入的反应. 这种内在的活动,而不仅仅是外部刺激,驱动大脑反应,影响功能连接研究.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 目前的大脑活动的计算模型很难区分直接的感官反应和内在的神经动力学.
- 了解外部刺激与大脑内部网络活动之间的相互作用对于准确的建模至关重要.
研究的目的:
- 开发和应用一种新的计算模型,使即时感官反应与内在大脑动态脱而出.
- 研究大脑内在的反复活动如何影响神经对外部刺激的反应.
主要方法:
- 应用一个带有外部输入 (VARX) 的矢量-自行回归模型来对人类的内记录.
- 从功能连接和编码模型中整合概念.
- 对各种感官刺激的神经反应的分析,包括场景剪辑,眼睛运动和声音.
主要成果:
- VARX模型成功地将外部刺激效应与内在的循环大脑动态分开.
- 发现内在的大脑动态增强和延长神经对感官刺激的反应.
- 由于没有考虑内在动态,导致识别虚假的反复连接.
- 与休息相比,观看电影期间的反复连接性下降.
- 外部刺激可以减少内在的神经噪声,感官区域显示出主要是外向连接,而更高阶区域显示出主要是输入连接.
结论:
- 大脑的内在动态在响应外部视听刺激时起着主导作用.
- 即使在休息期间也可以观察到大脑的内在活动,显著地塑造了它对感官输入的反应.
- 准确的计算模型必须考虑外部刺激和内在神经网络属性.
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