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Updated: Jun 9, 2025

Author Spotlight: Functional Site-Directed Fluorometry in Native Cells to Study Skeletal Muscle Excitability
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使用AlphaFold2探索电压导入的通道构造和蛋白质-蛋白质相互作用

Diego Lopez-Mateos1,2, Kush Narang1, Vladimir Yarov-Yarovoy1,2,3

  • 1Department of Physiology and Membrane Biology, University of California School of Medicine, Davis, CA 95616.

bioRxiv : the preprint server for biology
|October 28, 2024
PubMed
概括

像AlphaFold2这样的深度学习模型可以预测多个电压关闭的 (NaV) 通道构造,帮助药物发现. AlphaFold Multimer准确地模拟了与关键合作伙伴的NaV通道综合体,揭示了改变的结构景观.

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