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Updated: Jun 9, 2025

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具有降低PAR4反应性的小鼠显示静脉血栓塞和血小板前凝剂活性降低

Elizabeth A Knauss1, Johana Guci1, Norman Luc2

  • 1Case Western Reserve University, School of Medicine, Department of Pharmacology, Cleveland, OH United States.

bioRxiv : the preprint server for biology
|October 28, 2024
PubMed
概括

在PAR4 (rs2227376) 中的一个遗传变异减少了血栓生成,降低了静脉血栓栓塞 (VTE) 的风险. 这项研究证实了小鼠中PAR4-322L突变的保护机制,突出了PAR4信号传导.

关键词:
动物模型动物模型血小板是血液中的血小板.蛋白酶激活受体4的受体单个核酸的多形态.血素受体的受体是什么

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