在复杂的嗅觉记忆任务中,所需的是内膜皮层,而不是前膜皮层
Dahae J Jun1, Rebecca Shannon1, Katherine Tschida1
1Department of Psychology, Cornell University, 211 Uris Hall Ithaca, NY 14853 United States.
bioRxiv : the preprint server for biology
|October 28, 2024
概括
脑下皮层 (IL) 对于记忆控制至关重要. 抑制IL活性可以防止反向干扰,这表明它在新学习过程中抑制旧记忆的作用.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 行为神经科学 行为神经科学
背景情况:
- 中间前额叶皮层 (mPFC) 对记忆和行为灵活性至关重要.
- 截然不同的分区域,前边缘 (PL) 和下边缘 (IL),在记忆检索和抑制方面提出了不同的角色.
研究的目的:
- 研究mPFC的PL和IL亚区在解决记忆干扰方面的特定作用.
- 为了确定IL是否参与抑制以前获得的记忆,从而干扰新的学习.
主要方法:
- 化学遗传学 (DREADDs) 用于抑制mPFC中的神经元活动.
- 鼠被训练在一个有条件的歧视任务与冲突的气味歧视问题 (集A和B).
- 一个中期会话交换器在高干扰条件下测试了记忆检索,检查了PL和IL的失活.
主要成果:
- 对照大鼠在学习了B组后显示出A组记忆的检索受损,这表明有追溯作用的干扰.
- 与对照组相比,PL无活化没有改变性能.
- IL无活化取消了追溯干扰效应,这表明IL在记忆抑制中起着关键作用.
结论:
- 下边缘皮层 (IL) 在解决干扰所需的记忆控制过程中起着至关重要的作用.
- 似乎IL对于积极抑制与当前目标相冲突的先前学习的记忆的检索至关重要.
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