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Updated: Jun 9, 2025

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model
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Published on: March 9, 2022

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通过重建人类线粒体的末端连接来工程 mtDNA 删除

Yi Fu, Max Land, Ruobing Cui

    bioRxiv : the preprint server for biology
    |October 28, 2024
    PubMed
    概括

    科学家在人类细胞中设计了特定的线粒体DNA (mtDNA) 删除,揭示了75%的删除值,导致严重的细胞功能障碍. 这一突破使mtDNA删除疾病的更好的建模和潜在的治疗开发成为可能.

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