丹佛动物园的狮子,老虎和的SARS-CoV-2爆发
Emily N Gallichotte1, Laura Bashor1, Katelyn Erbeck2
1Department of Microbiology, Immunology and Pathology, Colorado State University.
bioRxiv : the preprint server for biology
|October 28, 2024
概括
SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 感染动物园动物,狮子呈现较高的病毒RNA和复发. 所有动物都产生了抗体,这表明只有一次人与动物的传播事件.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 动物传播疾病 动物传播疾病
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 已经在全球范围内感染了众多动物物种.
- 接近人类的动物,例如动物园里的动物,容易感染SARS-CoV-2感染,并且可以将其传播给/从人类.
研究的目的:
- 审查大猫的SARS-CoV-2感染情况,并描述动物园动物的特定爆发情况.
- 为了比较不同物种的感染动态,并确定传播和疾病严重性的风险因素.
主要方法:
- 在老虎和狮子中对SARS-CoV-2的文献综述.
- 丹佛动物园狮子,老虎和的SARS-CoV-2爆发的描述.
- 长度检测病毒RNA (vRNA) 和传染性病毒,以及抗体检测.
主要成果:
- 与老虎和子相比,狮子的vRNA水平和病毒复发率更高.
- 传染性病毒检测与高vRNA水平相关,并在感染早期发生.
- 所有动物在感染后四个月内都产生了强大的中和抗体标位.
- 爆发菌株 (三角洲系AY.20) 与罕见的人类变种相匹配,这表明单一的人对动物的溢出.
结论:
- 在易受感染的动物物种中,SARS-CoV-2感染的动态显著不同.
- 了解动物易感性和流行病学对于控制当前和未来动物传播疾病的传播至关重要.
- 动物园是人类溢出事件后跨物种SARS-CoV-2传播的潜在热点.
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