按需扣押有助于快速查的治疗方法
Yuzhang Chen1,2, Brian Litt3,4, Flavia Vitale2,3,4
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.
研究人员在患有慢性的小鼠中开发了一种按需的发作模型. 这种新方法可以更快,更相关的测试药物和干预疾病大脑的干预.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学 是一个学科.
- 的研究研究.
背景情况:
- 目前用于药物开发的动物模型在高吞吐量和病因相关性之间进行了权衡.
- 急性发作模型缺乏慢性的神经病理变化,而自发性发作模型由于不频繁的事件而耗时.
研究的目的:
- 在慢性性小鼠中开发一种新的,按需的发作模型,以进行更有效和更相关的治疗评估.
- 为了使"按需"的发作沉在患病的大脑电路中,以改善药物查.
主要方法:
- 在慢性性小鼠的海马体CA1区域同步主要细胞的机械方法.
- 简短的同步可靠地诱导了刻板印象,按需的行为发作.
- 测试了抗发作药物的有效性 (莱维西拉cetam,迪亚泽帕姆) 在停止诱导的发作.
主要成果:
- 在慢性性小鼠中,按需发作模仿了自发发作.
- 诱导性发作被常见的抗发作药物有效控制.
- 发作诱导疾病电路不同于那些天真的动物,强调模型的病因相关性.
结论:
- 开发的按需发作模型为评估治疗方法提供了更快,更有病因学的方法.
- 这种模型对于推进叶的药理学和闭环干预措施的发展至关重要.
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