针对性降解HPV上蛋白E6减少了宫癌的瘤负担

Tracess B Smalley1, Angelo Nicolaci1,2, Kim C Tran3

  • 1Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.

概括

研究人员开发了一种新型的蛋白质溶解向金氏体 (PROTAC) 来降解人类乳头瘤病毒 (HPV) E6蛋白质. 这种有针对性的降解通过刺激免疫反应,有效地抑制了HPV的瘤生长.

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