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Updated: Jun 9, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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基于负载的差异在两个tcrs的动态异构中识别相同的pMHC

Ana C Chang-Gonzalez1, Aoi Akitsu2,3,4, Robert J Mallis2,3,5

  • 1Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.

bioRxiv : the preprint server for biology
|October 28, 2024
PubMed
概括

对T细胞受体 (TCR) 的机械力量是抗原识别的关键. 模拟显示,TCRs中保存的动态质增强了微小的接触差异,导致了不同的机械反应和生物结果.

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Generation of Human Alloantigen-specific T Cells from Peripheral Blood

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Diversity of Antigen Receptors

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Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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