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Updated: Jun 17, 2026

Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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通过启用mRNA显示的机器学习模型评估循环脱水酶LyndD的基质范围

Emma G Steude, Henry Dieckhaus, Jarrett M Pelton

    bioRxiv : the preprint server for biology
    |October 28, 2024
    PubMed
    概括

    研究人员使用mRNA显示来研究像Lynd.D.这样的核糖体合成和翻译后修饰 (RiPP) 酶. 这种高通量方法使深度学习模型能够预测酶活性,并指导开发新的疗法.

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    相关概念视频

    Leaky Scanning02:28

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    During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...