对患有2型糖尿病的青少年进行8小时后限时饮食的随机控制可行性试验
Elizabeth Hegedus1, My H Vu2, Sarah Jeanne Salvy3
1Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism.
Journal of the Academy of Nutrition and Dietetics
|October 28, 2024
概括
晚期限时饮食 (lTRE) 对患有2型糖尿病 (T2D) 的青少年来说是可行的,在身体组成和血糖控制方面显示出潜在的益处. 建议进行进一步的研究,以优化这种干预,以获得更好的结果.
科学领域:
- 代谢健康 代谢健康
- 青少年医学 青少年医学
- 营养科学 营养科学
背景情况:
- 青少年的2型糖尿病 (T2D) 越来越令人担忧,对饮食干预的研究有限.
- 晚期限时饮食 (lTRE) 之前没有在这个人群中研究其对血糖控制和身体组成的影响.
研究的目的:
- 评估lTRE在患有T2D的青少年中的可行性和可接受性.
- 为了探索与长时间进食窗口的对照组相比,lTRE的初步疗效.
主要方法:
- 一项为期12周的随机对照可行性研究,涉及患有T2D的青少年 (13-21岁).
- 参与者被随机分配到 lTRE (8小时的进食窗口,下午12点至下午8点) 或对照组.
- 持续血糖监测 (CGM),HbA1c,%BMIp95和DEXA扫描被用于评估结果.
主要成果:
- 较高的招聘率 (75%) 和保留率表明可行性,在良好遵守 lTRE 和控制武器的情况下.
- lTRE显示BMIp95 (-3.4%) 显著降低,并且在该组内减少HbA1c (-0.4%) 和ALT (-31.1 U/L) 的趋势.
- 与对照组的增加 (+293.2 kcal/day) 相比,lTRE组的每日能量摄入量显著减少 (-271.4 kcal/day).
结论:
- lTRE对于患有T2D的青少年来说是一个可行的和可接受的干预措施.
- 这项研究表明,lTRE对人体组成和血糖控制有潜在的益处,需要进一步调查.
- 未来的干预措施应该建立在这些发现的基础上,以加强对改善结果的坚持和参与.
相关概念视频
01:16Insulin: Dosing Regimen and Adverse Effects
148
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
148
01:36Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
01:23Binge Eating Disorders
51
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
51
01:22Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
01:22Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K