临床病理因素和AR-LBD突变在早期和晚期割抵抗性前列腺癌中
Monu Deswal1, Durgavati Yadav1, Vinay Kumar2
1Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
Cancer management and research
|October 28, 2024
概括
了解前列腺癌的进展是关键. 高格里森得分预测早期的抵抗割的前列腺癌 (CRPC),而较低的纳迪尔PSA表明晚期的进展. 对生物标志物的进一步研究是必要的.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 癌症生物学 癌症生物学
背景情况:
- 前列腺癌 (PCa) 呈现出显著的生物异质性,使其进展和管理复杂化.
- 了解预测早期与晚期进展为抵抗割的前列腺癌 (CRPC) 的因素对于改善患者护理至关重要.
研究的目的:
- 确定与CRPC早期和晚期进展相关的临床和病理变量.
- 探索雄激素受体 (AR) 基因序列与CRPC发育之间的相关性.
主要方法:
- 在2018年1月至2022年1月期间诊断的98名CRPC患者的回顾性分析.
- 根据割耐药性时间 (TTCR) 将患者分为四分之一的分层.
- 基于临床,病理和AR-LBD序列数据的早期CRPC (6-12个月TTCR) 和晚期CRPC (38-120个月TTCR) 组的比较.
主要成果:
- 割抵抗的中位时间为25±26.44个月.
- 较高的格里森得分 (≥7) 与早期CRPC发育有显著的关联 (p<0.001).
- 下极点PSA水平与晚期CRPC进展有显著的相关性 (p<0.005).
- 鉴定了AR基因第7个内部区域的同卵性突变,可能会影响CRPC中的拼接变异.
结论:
- 前列腺癌向CRPC的进展是异质的,耐药性的时间范围广泛.
- 早期年龄,高初始PSA和高格里森得分与早期CRPC有关.
- 下极点PSA是晚期CRPC进展的预测指标.
- 没有发现任何显著的基因组突变,突显了对预测生物标志物的进一步研究的需要.
相关概念视频
01:30Coronary Artery Disease I: Introduction
3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
01:20Disorders of the Male Reproductive System
342
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
342