一项关于急性尾炎中血液炎症标志物的临床诊断性能前性比较研究
Zhenchao Yuan1, Changhua Chen1, Kefang Liu1
1Department of Clinical Laboratory, People's Hospital of HuiLi City, Huili, Sichuan Province, 615100, People's Republic of China.
Journal of inflammation research
|October 28, 2024
概括
中性粒细胞凝酶相关的卡林 (NGAL) 和C反应蛋白 (CRP) 显示出对急性尾炎 (AA) 的有希望的诊断效用. 虽然NGAL和CRP的性能类似,但结合标记物对AA的诊断准确性提供了有限的改善.
科学领域:
- 医学诊断 医学诊断 医学诊断
- 临床生物化学 临床生物化学
- 炎症标记物 炎症标记物
背景情况:
- 急性尾炎 (AA) 的成像技术已经进步,但实验室生物标志物缺乏足够的特异性和灵敏性.
- 目前的临床实践依赖于不足的实验室测试来准确的AA诊断.
研究的目的:
- 为了研究常用的血液炎症标志物对急性尾炎的诊断效用.
- 评估血中性粒细胞凝酶相关性脂卡林 (NGAL),白细胞计数 (WBC),中性粒细胞百分比 (NEU%),中性粒细胞与淋巴细胞比率 (NLR) 和C反应蛋白 (CRP) 在诊断AA的有效性.
主要方法:
- 一项前性研究涉及399名参与者:200名AA,100名腹痛 (AP) 和99名健康对照 (HC).
- 在所有参与者的血NGAL,WBC,NEU%,NLR和CRP的测量.
- 使用接收器操作特征 (ROC) 曲线和德隆测试来评估诊断性能.
主要成果:
- 生物标志物水平逐渐增加,从HC到AP到AA组 (p<0.05).
- 血NGAL和NEU%被确定为AA的显著风险因素.
- 与NEU和WBC相比,血NGAL,CRP和NLR在区分AA和HC方面显示出更高的诊断性能.
- NGAL和CRP在区分AA与非尾炎组方面表现出可比且有利的诊断疗效.
结论:
- 在急性腹部患者中,NGAL,CRP,WBC,NEU%和NLR显著升高.
- NGAL和NEU%可以作为AA发病率的独立风险因素.
- NGAL和CRP对AA具有相似的,有利的诊断性能,结合标记物的额外益处有限.
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