自行纳米乳化药物输送系统与聚合物模态系统的glibenclamide相结合,用于增强药物溶解和稳定性
Abdelrahman Y Sherif1, Mohamed Abbas Ibrahim1
1Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
ACS omega
|October 28, 2024
概括
一种新的聚合物无形系统 (PAS) 增强了glibenclamide (GB) 在自纳米乳化药物递送系统 (SNEDDS) 中的稳定性和溶解. 这种综合方法克服了药物降解问题,改善了酸性药物的生物可用性.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 自行纳米乳化药物递送系统 (SNEDDS) 增强了疏水性药物溶解和生物可用性.
- 像 Glibenclamide (GB) 这样的酸性药物在 SNEDDS 中面临着降解挑战.
- 整合无形形式的药物可以提高溶解性和稳定性.
研究的目的:
- 研究使用聚合物无形系统 (PAS) 来无形化基胺 (GB).
- 评估无形GB在SNEDDS配方中的整合.
- 评估PAS对GB稳定性和SNEDDS内部溶解的影响.
主要方法:
- 制备液体-SNEDDS (L-SNEDDS),固体-SNEDDS (S-SNEDDS) 和联合SNEDDS+PAS配方的方法.
- 使用zeta-sizer,SEM,DSC,PXRD和溶解测试进行表征.
- 在稳定室化后评估GB完整性.
主要成果:
- 冷干燥 (FD) 证明在GB无形化方面优于微波 (MW).
- SNEDDS配方增加了GB溶解效率 (DE),但发生了降解.
- 通过FD制备的PAS显著增加了GB DE从2.5%增加到84.2%,并防止了降解.
结论:
- 结合的SNEDDS + PAS系统有效地提高了酸性药物的稳定性.
- 这种方法有助于将无形药物纳入SNEDDS.
- 开发的系统显示了改善具有挑战性的药物化合物的输送的前景.
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