移植后的血液异常和移植后的贫血与移植功能的关联
Sindhura Lakshmi Koulmane Laxminarayana1, Shreya Jayaram2, Shilna Muttickal Swaminathan2
1Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education,, Manipal, Karnataka, 576104, India.
移植后贫血 (PTA) 在移植后很常见,随着时间的推移而改善. 第一个星期的严重PTA与移植功能障碍有关,但长期的移植功能无论PTA状态如何,都相似.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 移植手术 移植手术
背景情况:
- 血液学异常常见于移植后,影响患者和移植结果.
- 这些异常的模式在全球范围内有所不同,亚洲人口的数据有限.
- 本研究侧重于亚洲队列中移植后的第一年.
研究的目的:
- 评估移植患者血液学异常的患病率和模式.
- 评估移植后贫血 (PTA) 和移植功能之间的关联.
- 为了调查其他细胞衰竭和移植后的红细胞瘤.
主要方法:
- 在106名移植患者 (2014-2019年) 的单中心回顾性研究中.
- 在移植后12个月内收集的数据.
- 血液学参数和移植功能的分析.
主要成果:
- 移植后贫血 (PTA) 的患病率:98% (1周),75% (1个月),35% (3个月),32% (6个月),27% (12个月).
- 其他细胞衰竭:白血病 (43.4%),血小板衰竭 (33.2%),全细胞衰竭 (15.1%).
- 在第1周严重的PTA与移植功能障碍相关 (p=0.04);在6个月和12个月时,无论PTA (p=0.50),移植功能都类似.
结论:
- 血液学异常,特别是PTA,在移植后的早期非常普遍,但往往会消失.
- 发现了白血病,血小板衰竭和全细胞衰竭,分别与药物和感染有关.
- 早期严重的PTA与最初的移植功能障碍相关,但长期的结果是可比的.
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