对于患有Enterococcus faecalis内心炎的患者,使用连续输注IVzylpenicillin加IV ceftriaxone的门诊亲肠道抗菌疗法
Simon Briggs1, Eamon Duffy1, Hasan Bhally2
1Infectious Disease Unit, Auckland City Hospital, Te Whatu Ora Te Toka Tumai Auckland, Auckland, New Zealand.
JAC-antimicrobial resistance
|October 28, 2024
概括
门诊亲肠道抗微生物疗法 (OPAT) 连续输液 IV 青素和 ceftriaxone 是有效的,对Enterococcus faecalis 内心炎. 这种治疗方案允许稳定的患者在家中完成抗生素疗程.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- Enterococcus faecalis内心炎往往使患者在完成静脉注射抗生素之前就能出院.
- 关于这些患者的门诊治疗选择的数据有限.
研究的目的:
- 评估门诊亲肠道抗微生物疗法 (OPAT) 对于Enterococcus faecalis内心炎的结果.
- 评估一种特定的治疗方案,即IV连续输注zylpenicillin加 bolus/IV连续输注 ceftriaxone.
主要方法:
- 对接受至少2周OPAT治疗E. faecalis内心炎的成年患者的回顾性审查.
- 治疗包括IV连续输注zylpenicillin和玻尿酸/持续输注IV ceftriaxone.
- 2019年7月至2022年9月期间从奥克兰和基督城地区收集的数据.
主要成果:
- 包括44名患者,平均年龄为80岁.
- 12个月的治愈率为57% (25名患者),其中20%接受抗生素抑制,18%死亡.
- 复发发生在5%的患者中,与使用 gentamicin 的历史队列相比没有差异.
结论:
- 连续输注IVzylpenicillin加 ceftriaxone是一种可行的OPAT选择,用于E. faecalis内心炎.
- 该方案支持在医院出院后需要进一步抗生素治疗的患者的护理过渡.
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