血清雷丁醇结合蛋白4在患有基本高血压和2型糖尿病的个体:一个横截面研究
Anand G Jadhao1, Kapila B Gaikwad2, Ravi R Yadav3
1Department of Physiology, SRMSIMS, Bareilly, Uttar Pradesh, India.
Journal of family medicine and primary care
|October 28, 2024
概括
升高的视网醇结合蛋白4 (RBP4) 水平与初级高血压和2型糖尿病有关. 这一发现表明RBP4是这些相互关联的心脏代谢疾病的潜在生物标志物.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 像初级高血压和2型糖尿病这样的心脏代谢障碍对全球健康构成重大挑战.
- 视网醇结合蛋白4 (RBP4),一种阿迪波金,越来越多地被认为是其在代谢和心血管功能障碍中的作用.
- RBP4与胰岛素抵抗及其并发症有关,包括高血压.
研究的目的:
- 在患有初级高血压和2型糖尿病的患者中检查血清雷丁醇结合蛋白4 (RBP4) 度.
- 探索RBP4水平,胰岛素抵抗和心血管参数之间的关联.
- 为管理相互关联的心脏代谢疾病的诊断和治疗策略提供见解.
主要方法:
- 一项涉及印度北部119名参与者 (58名患有基本高血压和2型糖尿病,58名健康对照) 的横截面研究.
- 使用ELISA量化血清RBP4水平,以及胰岛素抵抗标志物和血压测量.
- 使用SPSS 20.0.0.进行了统计分析,包括t测试和皮尔森相关性,使用SPSS 20.0.0.
主要成果:
- 患有基本高血压和2型糖尿病的参与者年龄较大,血脂不良的患病率更高.
- 与对照组相比,精性高血压和2型糖尿病组的血清RBP4度显著升高.
- 相关性分析表明,RBP4水平与代谢和心血管参数之间存在关联.
结论:
- 血清RBP4的升高表明它有可能成为一种新的生物标志物,用于原发性高血压和2型糖尿病的共享病理生理学.
- RBP4可能是代谢,脂质和心血管功能障碍之间的关键联系.
- 这些发现强调了需要采取整体干预措施,解决这些条件的复杂相互作用.
相关概念视频
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Hypertension I: Introduction
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
61
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
61
Alterations in Blood Pressure
1.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.2K


