变性人的胆囊疾病:与性别肯定激素治疗的关联
Tomasz Tabernacki1,2, Matthew Loria1,2, Stephen Rhodes2
1Case Western Reserve University School of Medicine, Cleveland, USA.
International journal of transgender health
|October 28, 2024
概括
性别确认激素治疗 (GAHT) 可能会增加使用雌激素的跨性别女性的胆囊疾病风险. 丸激素治疗对跨性别男性的胆囊疾病风险没有影响.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 性别确认激素治疗 (GAHT) 对变性人来说至关重要.
- 胆囊疾病 (GBD) 影响10-15%的美国人口,与雌激素治疗有关.
- 在跨性别人群中,GAHT对GBD风险的影响还未得到充分研究.
研究的目的:
- 调查GAHT与胆囊疾病 (GBD) 风险之间的关联.
- 评估在接受激素治疗的跨性别女性和男性中GBD患病率.
- 为了比较跨性别者在GAHT治疗中与没有接受干预的跨性别者中的GBD风险.
主要方法:
- 来自TrinetX数据库的非身份医疗记录的分析.
- 包括52,847名跨性别男性和38,114名跨性别女性.
- 倾向性得分与年龄,种族和BMI等风险因素的控制匹配.
主要成果:
- 接受激素治疗 (TWHT) 的跨性别女性的10年GBD概率 (4.69%) 比未接受治疗 (TWNI) 的女性 (1.88%) 高.
- 在TWHT患者中,胆囊切除术的发生率显著更高 (1.10%对0.57%).
- 接受激素治疗的跨性别男性 (TMHT) 与没有接受治疗的男性 (TMNI) 相比,在GBD率上没有显著差异 (3.15%对3.87%).
结论:
- 在跨性别女性中,以雌激素为基础的GAHT与胆囊疾病 (GBD) 的风险增加有关.
- 在跨性别男性中,以丸激素为基础的GAHT没有显示出对GBD的保护作用.
- 这项研究是首次在跨性别人群中检查GBD负担和GAHT影响.
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