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人类和肠道微生物群在代谢活跃的超级生物体中的协同作用:心血管视角
Matteo Antonio Russo1, Matteo Puccetti2, Claudio Costantini3
1San Raffaele IRCSS, Rome, Italy.
Frontiers in cardiovascular medicine
|October 28, 2024
概括
肠道微生物群通过免疫激活影响心血管疾病 (CVD). 来自肠道细菌的托芬代谢物影响炎症和免疫调节,为心血管疾病提供了新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 心脏病学 心脏病学
背景情况:
- 尽管取得了进展,心血管疾病 (CVD) 仍然是导致死亡的首要原因.
- 了解致病机制对于有效的心血管疾病治疗至关重要.
- 肠道微生物组在免疫和炎症途径中的作用在心血管疾病中越来越被认可.
研究的目的:
- 审查免疫系统和炎症在心血管疾病中的作用.
- 探索肠道微生物组衍生型的托代谢物如何影响心脏免疫病理学.
- 突出潜在的微生物群为心血管疾病的治疗策略.
主要方法:
- 文献综述侧重于心血管疾病中的免疫炎症激活.
- 分析肠道微生物对心血管疾病的影响.
- 检查托代谢及其在阿里碳水化合物受体 (AhR) 上的融合.
主要成果:
- 肠道微生物群的代谢物,特别是基衍生物,调节与心血管疾病相关的免疫反应.
- 通过肠道微生物群介导的免疫系统调节和抗炎途径在各种心血管疾病中至关重要.
- 托代谢通过AhR将宿主和微生物通路与免疫恒常连接起来.
结论:
- 肠道微生物群通过免疫调节在心血管疾病的发病过程中发挥着重要作用.
- 准肠道微生物组衍生代谢物,如英多尔,为心血管疾病提供了新的治疗途径.
- 进一步研究以微生物为中心的策略对于打击心血管疾病至关重要.
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