在一个农村国家的医疗保健专业人员中,SARS-CoV-2 血清阳性
Brianna Wright1, Daniel Kang1, Allison Schuette2
1Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|October 28, 2024
概括
这项研究发现,卫生保健工作者中SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 抗体转化和逆转率较低. 接种疫苗和口罩的使用有助于预防感染.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 评估SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 抗核囊抗体血清转换和血清转换率对于了解人口免疫力至关重要.
- 评估SARS-CoV-2血清转化和COVID-19 (冠状病毒疾病2019) 的风险因素,以及医护人员的风险感知,为职业健康提供了洞察力.
- 了解农村学术医疗保健环境中的这些动态对于有针对性的公共卫生干预非常重要.
研究的目的:
- 为了评估SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 抗核体 (抗N) 血清转化和血清转化率.
- 为了确定与SARS-CoV-2血清转化相关的风险因素.
- 评估COVID-19 (冠状病毒疾病2019) 在农村州的学术医疗中心员工中的风险感知.
主要方法:
- 一个农村国家的302名学术医疗保健中心员工参与了这项研究.
- 参与者每隔3个月提供血液样本 (T0,T3,T6,T9) 进行血清学检测.
- 使用后勤回归来确定基线 (T0) 血清阳性风险因素.
主要成果:
- 在基线 (T0) 时,28.4%的参与者为SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 抗N抗体呈阳性.
- 在T3,T6和T9的血清转化率分别为3.0%,3.3%和7.8%,这些人最初是血清阴性.
- 护理人员的身份 (OR, 2.37) 和与非家庭成员在工作之外的密切接触 (OR, 2.91) 增加了血清阳性概率,而疫苗接种 (OR, 0.05) 和面罩使用 (OR, 0.36) 是保护性的.
结论:
- 该研究观察到卫生保健员工队列中SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 血清转换和血清转换率较低.
- 公共卫生措施,包括疫苗接种,口罩使用和社交距离,与SARS-CoV-2病毒阳性概率的降低有显著关联.
- 这些发现强调了实施的感染预防策略在减轻医疗保健机构内的SARS-CoV-2传播方面的有效性.
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