介质细胞干细胞和组织生物工程应用在绵羊中作为理想模型
Talita D'Paula Tavares Pereira Muniz1, Mariana Correa Rossi2, Vânia Maria de Vasconcelos Machado3
1Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), 18.618-681, Botucatu, Sao Paulo, Brazil.
Stem cells international
|October 28, 2024
概括
生物材料通过支持细胞分化和扩张来增强介质干细胞 (MSC) 治疗以修复组织. 本综述涵盖了最近的MSC和生物材料方法,特别是在绵羊模型中.
科学领域:
- 组织工程是组织工程.
- 再生医学是一种再生医学.
- 生物材料科学是生物材料的科学.
背景情况:
- 组织工程采用诸如生长因子,金属植入物,3D生物打印和细胞疗法等技术.
- 介质干细胞 (MSC) 在再生医学中非常重要,因为它们具有自我更新,免疫调节,繁殖和分化能力.
- 在肌肉骨疾病中,MSC疗法为器官移植提供了一个有希望的替代方案.
研究的目的:
- 审查最近发生的介质干细胞 (MSC) 组织修复方法的进展.
- 突出生物材料在支持MSC差异化和扩张中的作用.
- 分析实验,临床和临床前研究,重点是羊模型.
主要方法:
- 实验,临床和临床前研究的文献综述.
- 专注于涉及介质干细胞 (MSC) 和生物材料的研究.
- 包括使用绵羊模型的研究.
主要成果:
- 生物材料通过调节它们的组成,机械性能,多孔性和地形学,显著影响MSC的分化和扩张.
- 目前正在探索各种组织工程技术,以提高MSC的治疗潜力.
- 绵羊模型为基于MSC的治疗方法的临床前评估提供了宝贵的见解.
结论:
- 生物材料对于优化组织工程中基于MSC的疗法至关重要.
- 对生物材料-MSC相互作用的进一步研究对于推进再生医学至关重要.
- 临床前研究,特别是在绵羊模型中,是将MSC疗法转化为临床应用的关键.
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