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长途寻找小瘤:寻找胰岛素瘤的狩猎

Durairaj Arjunan¹, Ashley B Grossman^2,3,4, Harmandeep Singh⁵

¹Department of Endocrinology, PGIMER, Chandigarh 160012, India.

JCEM case reports

|October 28, 2024

概括

一种罕见的胰岛素瘤很难用标准成像来定位. 一个专门的-68Exendin-4PET/CT扫描成功地确定了瘤,使手术切除和治疗患者的低血糖症.

科学领域:

内分泌学在内分泌学.
核医学就是核医学.
手术瘤学手术瘤学

背景情况:

超胰岛素性低血糖症可能是由胰岛素瘤,一种罕见的胰腺瘤引起的.
隐性胰岛素瘤的定位是一个诊断挑战,通常需要先进的成像技术.

研究的目的:

报告一个成功局部化和治疗隐性胰岛素瘤的病例.
为了突出-68 Exendin-4 PET/CT 在识别难以捉摸的胰岛素瘤中的实用性.

主要方法:

一名35岁的女性患有复发性低血糖症,接受了广泛的成像,包括MRI,内镜超声波和68Ga-DOTATATE PET/CT,没有瘤局部化.
进行了-68 Exendin-4 PET/CT 扫描,确定了胰腺病变.
术内超声检查证实了病变,随后进行了外科切除.

主要成果:

68Ga-Exendin-4 PET/CT扫描精确地定位了胰腺未燃烧过程中的1.5厘米病变.
组织病理学证实了一种差异化良好的胰腺神经内分泌瘤 (胰岛素瘤).
手术后,患者经历了低血糖事件的完全消失和正常化的葡萄糖水平.

结论:

在传统方法失败时,-68 Exendin-4 PET/CT 是一种非常有效的工具来定位隐藏的胰岛素瘤.
及时的手术干预,通过准确的定位来促进,导致胰岛素瘤的治愈结果.
患者获得先进的成像设施,即使在本地没有,对于管理罕见的内分泌瘤至关重要.

关键词:

68Ga-DOTATATE PET/CT 是一种 68Ga-DOTATATE 的一种.68Ga-exendin-4 PET/CT 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 含有 68Ga-exendin-4 超胰岛素高血糖低血糖症低血糖症是一种低血糖症.胰岛素瘤是一种胰岛素.隐性胰岛素瘤是一种隐性胰岛素瘤 pNET pNET 是一个网络.

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