酸在抗瘤免疫中的作用
Federica Cappellesso1,2, Massimiliano Mazzone3,4, Federico Virga5
1Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium. Federica.Cappellesso@vub.be.
Cancer cell international
|October 28, 2024
概括
瘤的酸度和乳酸盐会损害抗癌免疫反应. 针对这些因素,特别是通过单碳酸盐载体 (MCTs),可以提高免疫治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
背景情况:
- 癌细胞重新连接新陈代谢,导致由于乳酸积累而形成酸性瘤微环境 (TME).
- 这种酸性TME (pH低至5.6) 破坏了酸平衡,促进了恶性病变的进展.
- 酸度和乳酸盐对先天性和适应性免疫细胞产生负面影响,阻碍抗瘤反应,降低免疫疗法的有效性.
研究的目的:
- 审查酸度和乳酸盐对TME内的免疫细胞的影响.
- 突出单碳酸盐运输体 (MCT) 和其他溶液载体运输体 (SLC) 在pH调节和乳酸盐运输中的作用.
- 讨论针对pH或乳酸的策略,以提高抗瘤免疫力.
主要方法:
- 文献综述总结当前的知识.
- 专注于酸度和乳酸盐对免疫细胞的功能,代谢和表观遗传影响.
- 讨论乳酸盐和二碳酸盐交换中的载体作用 (MCT,SLC).
主要成果:
- 酸性和乳酸盐抑制了抗瘤免疫细胞的功能.
- MCT和SLC是调节TME pH和乳酸盐水平的关键参与者.
- 针对这些代谢因素显示出增强抗瘤免疫力的前景.
结论:
- 与瘤相关的酸度和乳酸盐显著损害了抗癌免疫反应.
- 单碳酸盐运输体 (MCT) 和相关的SLC对于管理TME代谢失调至关重要.
- 调节TME pH和乳酸是一种有前途的治疗策略,可以提高抗瘤免疫力和免疫治疗结果.
关键词:
酸性 酸性 酸性表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.免疫反应的免疫反应.免疫治疗是一种免疫疗法.乳酸盐是一种乳酸盐.在SLC中,SLC是SLC.瘤微环境中的微环境它们的pH值为pH.更多相关视频
09:01Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
296
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.5K
相关概念视频
Tumor Immunotherapy
486
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
486
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Cytotoxic T Cells-mediated Immune Response
853
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
853
T Cell Activation and Clonal Selection
674
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
674
Cancer Vaccines
342
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
342
The Intrinsic Apoptotic Pathway
6.4K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.4K
