联合向GPX4和BCR-ABL氨酸激酶可以选择性地破坏BCR-ABL+白血病干细胞

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Chengwu Zeng1,2, Dingrui Nie3,4, Xianfeng Wang3

  • 1Guangzhou First People's Hospital, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China. chengwuzeng@gzhmu.edu.cn.

Molecular cancer
|October 28, 2024
PubMed
概括

与氨酸激酶抑制剂 (TKIs) 结合的迪苏尔菲拉姆 (DSF) 通过GPX4降解诱导铁亡,有效向抗BCR-ABL+白血病细胞和白血病干细胞 (LSCs). 这种双重抑制为白血病治疗提供了一个有前途的策略.

关键词:
在BCR-ABL+白血病中.迪苏尔菲拉姆 (Disulfiram) 是一种铁性化 (ferroptosis) 是一种在GPX4中使用GPX4.铁氨酸激酶抑制剂 铁氨酸激酶抑制剂

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