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牙周状况和唾液微生物群是区分病的潜在指标:一项探索性研究
Shaoying Duan1, Meiying Shao2, Chenchen Zhang1
1National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus & State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, Sichuan, China.
BMC microbiology
|October 28, 2024
概括
病患者表现出改变的口腔微生物群和牙周变化,Aggregatibacter和Catonella被确定为潜在的生物标志物. 暴露于可呼吸的晶体二氧化会影响口腔健康,并可能影响病的发展.
科学领域:
- 职业健康 职业健康 职业健康 职业健康
- 微生物学 微生物学
- 牙周病学 牙周病学
背景情况:
- 病是全球重要的职业健康问题.
- 人们越来越认识到口腔微生物群在肺部疾病中的作用.
- 牙周病,口腔细菌和病之间的联系存在有限的研究.
研究的目的:
- 为了研究牙周状况,唾液微生物组合和病之间的关系.
- 为了确定潜在的口腔微生物生物标志物用于病检测.
主要方法:
- 横截面研究比较病患者和健康对照组.
- 牙周检查包括临床附着损失 (CAL),探针出血 (BOP) 和牙周口袋 (PD).
- 16S核糖体RNA测序分析了唾液微生物群;统计分析确定了生物标志物.
主要成果:
- 与对照组相比,病患者的CAL较差,但BOP和PD改善.
- 牙组织显示了α-平滑肌动蛋白和纤维动蛋白的表达增加.
- 在病患者中,唾液微生物群的多样性较低,Aggregatibacter和Catonella被确定为潜在的生物标志物.
结论:
- 病与特定的牙周变化和改变的口腔微生物群有关.
- 减少口腔微生物群多样性和聚合菌和卡托内拉菌的存在可能表明有病.
- 暴露于可呼吸的晶体二氧化会对口腔健康和口腔微生物组合产生不利影响,可能导致病.
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