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炎症性肠病,结肠炎和癌症:揭开慢性炎症的联系
Vahid Khaze Shahgoli1,2, Saeed Noorolyai1, Mahya Ahmadpour Youshanlui1
1Faculty of Medicine, Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
International journal of colorectal disease
|October 28, 2024
概括
慢性炎症驱动着结肠炎相关的结肠直肠癌 (CA-CRC),通过创造一种支持瘤的环境. 控制炎症,优化炎症性肠病 (IBD) 管理,以及新疗法是预防CA-CRC的关键.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 慢性炎症是发展疾病的关键因素,包括癌症.
- 大肠炎相关结肠直肠癌 (CA-CRC) 是患有炎症性肠病 (IBD) 的个体的风险增加.
研究的目的:
- 审查慢性炎症和CA-CRC之间的联系.
- 探索CA-CRC中炎症的分子途径和临床影响.
主要方法:
- 文学叙事审查. 文学叙事审查.
- 在PubMed,Scopus和科学网络 (2000-2024) 中进行了搜索.
- 包括关于炎症在CA-CRC中的作用的临床和机制研究.
主要成果:
- 持续的结肠炎症促进了一个支持瘤的环境.
- 炎症驱动CA-CRC的启动和进展.
- 分子机制将炎症与CA-CRC发育联系起来.
结论:
- 控制慢性炎症对于预防CA-CRC至关重要.
- 优化IBD管理和定期查至关重要.
- 针对炎症和微生物组调节的新兴疗法显示出降低CA-CRC风险的希望.
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