上道泌尿道癌:流行病学,表现和高风险的特有种群
Cassra B Clark1, Meghan Matheny, Jay D Raman
1Department of Urology, Penn State College of Medicine, Penn State University, Hershey, Pennsylvania, USA.
Current opinion in urology
|October 28, 2024
概括
上道泌尿道癌 (UTUC) 是罕见的,但通常在晚期被诊断出来. 在UTUC患者中早期识别林奇综合征对于及时的遗传咨询和管理至关重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 上道泌尿道癌 (UTUC) 仅占泌尿道癌的一小部分.
- 在高阶段,UTUC经常出现肌肉侵袭,影响预后.
- 相当多的UTUC患者 (10%) 患有林奇综合征,需要进行遗传评估.
研究的目的:
- 审查UTUC流行病学,表现和高风险人群的现有证据.
- 突出林奇综合征查在UTUC诊断中的重要性.
- 为工商联合会的预防和干预策略提供信息.
主要方法:
- 在过去18个月内对当代出版物的审查.
- 分析主要泌尿病学协会的最新指南.
- 专注于流行病学数据和临床表现.
主要成果:
- 美国泌尿器官学会 (AUA) 和欧洲泌尿器官学会 (EAU) 最近发布的指导方针涉及工会管理.
- 更新的指导方针强调识别林奇综合征的危险因素.
- 对于高概率的林奇综合征病例,建议进行通用组织学检测和遗传咨询.
结论:
- 虽然UTUC很少见,但通常会出现晚期疾病和肌肉侵袭.
- 了解工商联合会的流行病学和风险因素对于有效的策略至关重要.
- 在UTUC患者中,对林奇综合征的及时评估至关重要.
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