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注意缺陷多动障碍和2型糖尿病之间的调解途径:来自双步和多变量门德尔随机化研究的证据
J Zhang1,2, Z K Chen1, R D Triatin1,3
1Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Epidemiology and psychiatric sciences
|October 28, 2024
概括
注意缺陷多动症 (ADHD) 的责任与2型糖尿病 (T2D) 的更高风险有因果关系. 关键的调解因素包括更高的体重指数 (BMI),增加的电视观看和较低的教育程度 (EA).
科学领域:
- 遗传学和流行病学
- 代谢障碍 代谢障碍 代谢障碍
- 神经发育障碍 神经发育障碍
背景情况:
- 2型糖尿病 (T2D) 是一个重大的全球健康挑战.
- 与一般人群相比,注意力缺陷多动症 (ADHD) 患者的T2D患病率更高.
- 了解ADHD和T2D之间的病因联系对于公共健康至关重要.
研究的目的:
- 调查ADHD和T2D之间的潜在因果关系.
- 识别和量化ADHD可能影响T2D风险的调解途径.
- 探索身体质量指数 (BMI),教育程度 (EA) 和久坐行为在这个协会中的作用.
主要方法:
- 采用双样本的门德尔随机化 (MR) 设计,利用遗传变异 (单核酸多态) 来预测ADHD和潜在调解者的责任.
- 用各种MR方法,包括混合专家方法,来评估基因预测的ADHD和T2D之间的关联.
- 应用了多变量MR来估计通过BMI,EA和电视观看等媒介的间接影响.
主要成果:
- 基因预测的ADHD责任与T2D的几率增加10%有关 (OR:1.10).
- 对于教育程度 (EA; 39.44%),体重指数 (BMI; 44.23%) 和看电视 (44.10%),观察到显著的调解效应.
- 体重指数和EA的联合调解效应占ADHD-T2D关联中最大的比例 (53.31%).
结论:
- 在ADHD责任和T2D风险之间存在潜在的因果,积极的关联.
- 较高的BMI,增加的电视观看和较低的EA是ADHD和T2D之间的关系的重要调解者.
- 针对BMI,久坐不动行为和EA的干预措施可能会降低ADHD患者的T2D风险.
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