相关实验视频

Updated: Jun 9, 2025

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Published on: February 24, 2023

可注射的自催化凝触发热,刺激抗癌免疫反应,防止术后瘤复发

Zhiping Rao¹, Yutong Zhu^1,2, Zhuang Chen¹

¹Lab of Molecular Imaging and Translational Medicine (MITM), Engineering Research Center of Molecular & Neuroimaging, Ministry of Education, School of Life Science and Technology, Xidian University & International Joint Research Center for Advanced Medical Imaging and Intelligent Diagnosis and Treatment, Xi'an, Shaanxi, 710126, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|October 28, 2024

概括

这项研究介绍了一种可注射的水凝平台,该平台结合过氧化铜和德西来通过热致死消除残留的三阴性乳腺癌 (TNBC) 细胞,显著减少瘤复发.

科学领域:

生物医学工程生物医学工程
癌症治疗癌症治疗
免疫学免疫学免疫学

背景情况:

三重阴性乳腺癌 (TNBC) 的术后复发是一个重大的临床挑战.
目前的免疫疗法由于免疫抑制和亡耐药性而面临局限性.
需要有效的策略来消除残留的瘤并增强抗瘤免疫力.

研究的目的:

开发一种可注射的凝平台,用于TNBC治疗.
结合铜过氧化物 (CP@Gel) 与丁氨酸 (DAC) 增强抗瘤作用.
为了研究用于消除残留TNBC和调节免疫抑制的热致死诱导.

主要方法:

设计了一个可注射的水凝封装自催化铜过氧化物 (CP@Gel) 平台.
CP@Gel与DNA甲基转移酶抑制剂达基 (DAC) 结合使用.
治疗平台的疗效在体内被评估,以抑制TNBC生长和复发.

主要成果:

联合DAC+CP@Gel处理导致持续释放过氧化铜,产生活性氧物种并激活caspase-3.
DAC 抑制了 Gsdme 甲基化,增加了 GSDME 蛋白质水平,并诱导了热.
在体内研究表明,局部瘤复发的消除率为67%.

结论:

开发的可注射水凝平台通过诱导热亡,有效地抑制了TNBC的生长和复发.
这种策略克服了亡耐药性,增强了免疫性,并调节了免疫抑制.
可注射的凝辅助热亡具有预防TNBC术后复发的显著潜力.

关键词:

这是一种水凝.免疫反应的免疫反应.手术后复发的情况.热致灭症是什么?三重阴性乳腺癌是什么?

更多相关视频

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma

Published on: November 15, 2024

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 7, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...