在怀孕期间,乙型肝炎病毒和甲状腺激素的关联
Jing Wang1, Xiaoqiong Yang, Xiuzhen Liang
1Department of Clinical Laboratory, Chongqing Red Cross Hospital (People's Hospital of Jiangbei District), Chongqing, China.
Medicine
|October 28, 2024
概括
甲状腺激素水平在感染乙型肝炎病毒 (HBV) 的孕妇中发生变化. 较高的HBVDNA负载与特定的甲状腺激素变化相关,需要对孕产妇和胎儿健康进行监测.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 产科 产科 产科 产科 产科
背景情况:
- 慢性乙型肝炎 (CHB) 在全球范围内影响孕妇.
- 甲状腺功能障碍在CHB患者中很常见.
- 怀孕期间甲状腺激素和HBV之间的相互作用需要进一步阐明.
研究的目的:
- 调查血清甲状腺激素水平与乙型肝炎病毒 (HBV) 的DNA负载和CHB孕妇的基因型之间的相关性.
- 为了比较HBV感染和未感染的孕妇之间的甲状腺激素概况.
主要方法:
- 观察性研究包括96名患有CHB的孕妇和50名对照.
- 测量血清甲状腺激素:FT3,FT4,TSH,TPOAb,TGAb在不同的怀孕阶段.
- 组间激素水平的比较和与HBVDNA负载和基因型的相关性分析.
主要成果:
- 与对照组相比,感染HBV的孕妇显示TSH和TPOAb水平升高.
- 阳性HBV-DNA女性的TPOAb和TGAb水平高于阴性HBV-DNA女性.
- 在HBVDNA负载和FT3/FT4水平之间存在显著的负相关性;与TGAb有正相关性.
- 不同HBV基因型的甲状腺激素水平没有显著差异.
结论:
- 在感染HBV的孕妇中,甲状腺激素水平发生显著变化.
- 乙型肝炎病毒的DNA负载与特定的甲状腺激素变化 (FT3,FT4,TGAb) 有关.
- 监测甲状腺激素和HBV DNA负载对于在怀孕期间管理HBV至关重要.
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