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Updated: May 6, 2026

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LEF1与肺腺癌患者的免疫抑制微环境有关

Xiaoqing Liu1, Chunlou Wang, Xiaoling Zhang

  • 1Department of Pathology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Medicine
|October 28, 2024
PubMed
概括

肺腺癌 (LUAD) 中高LEF1表达与免疫抑制性瘤微环境和较差的存活率相关. 这种转录因子会影响免疫细胞的透,影响瘤的进展.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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