在COVID-19感染2年后持续性肺功能障碍:一项观察性研究
Tejas Menon Suri1, Garima Srivastava, Sunil Kumar
1Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India.
Lung India : official organ of Indian Chest Society
|October 28, 2024
概括
长期呼吸道问题,如持续性呼吸不良和肺功能受损,在2019年新冠肺炎 (COVID-19) 幸存者中常见,感染后两年多. 女性的性别和在三角洲变种浪潮期间的感染与这些持久影响有关.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 持续性呼吸不良和肺功能受损是2019年新冠肺炎疾病 (COVID-19) 的已知的后果.
- 长期的结果,特别是感染后两年以后的长期结果,仍然在很大程度上没有特征.
研究的目的:
- 评估COVID-19感染后两年多的幸存者自我报告呼吸障碍和肺功能测试的趋势.
- 为了确定与持续性呼吸不良和肺功能障碍相关的临床人口因素,超过两年.
主要方法:
- 一个单一中心的观察性研究是在印度的一家后COVID诊所的患者身上进行的.
- 在COVID-19疾病后的两年内,评估了呼吸障碍和肺功能趋势.
- 使用后勤回归分析来确定与持续症状和肺功能受损相关的因素.
主要成果:
- 在231名参与者中,51.5%患有中度至重度的COVID-19. 呼吸障碍的患病率总体保持稳定 (39.4%对36.4%),但在中度至重度的组下降 (63%对54.6%).
- 持久性呼吸不良与女性性别,中度至重度的COVID-19和在三角洲波期间的感染有关.
- 在两年内,48.1%的受试者患有强迫生命能力 (FVC) 损伤,与年龄较大,女性性别和三角洲波感染有关.
结论:
- 持续性呼吸不良和肺功能受损是COVID-19幸存者的常见后果,感染后超过两年.
- 在三角洲变种浪潮期间的女性性别和感染是COVID-19后长期呼吸系统损伤的重要风险因素.
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