扩大了两个临床关注的Legionella pneumophila序列类型的地理分布
Jennafer A P Hamlin1, Natalia A Kozak-Muiznieks1, Jeffrey W Mercante1
1Division of Bacterial Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
mSphere
|October 28, 2024
概括
军团士兵们的军团
科学领域:
- 环境微生物学环境微生物学
- 传染病流行病学 传染病流行病学
背景情况:
- 流感性肺炎菌的序列类型 (ST) 213和222在20世纪90年代在美国出现.
- 这些STs越来越多地与社区获得的军团病 (LD) 相关.
- 与ST213不同,ST222已与多次美国LD爆发有关,不像ST213.
研究的目的:
- 分析与ST213和ST222相关的LD病例频率的变化.
- 为了确定ST213和ST222.2.之间的遗传差异.
- 了解这些性传播疾病的地理分布和流行率.
主要方法:
- 对1992年至2020年期间的LD病例数据的分析.
- 230个ST213/222分离物的全基因组测序.
- 进行比较基因组分析,以评估遗传多样性并识别差异化特征.
主要成果:
- 与ST213/222相关的LD病例在研究区域每年增加0.15例.
- 病例集中在密歇根州,纽约州,明尼苏达州和俄俄州.
- 在ST中和ST之间,高平均核酸标识 (ANI) 表明遗传多样性较低.
- 没有特定的基因组特征解释了观察到的地理分布和流行.
结论:
- ST213和ST222显示在美国的地理分布扩大.
- 尽管基因多样性较低,但这些性传播疾病越来越普遍.
- 需要进一步的研究来了解驱动其传播的因素.
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