在中介前额叶皮层中释放皮质类激素受体1的皮质类激素受体1介导厌恶耐药性酒精摄入
Miranda E Arnold1, Cecelia E Harber1, Lauren A Beugelsdyk1
1Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, 501 DW Brooks Drive, Athens, GA, 30602, USA.
Psychopharmacology
|October 28, 2024
概括
雌性小鼠表现出对抗厌恶的酒精摄入量,部分由中枢前额叶皮层中皮质释放激素受体1 (Crhr1) 介导. 阻止Crhr1降低了女性的酒精消耗,但没有男性.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 酒精使用障碍 (AUD) 的特点是持续饮酒,尽管负面的后果.
- 厌恶性抵抗,即当面对厌恶性刺激时继续饮酒,是研究AUD的一个关键模型.
- 在AUD中存在性别差异,女性经常表现出更高的厌恶抵抗力.
研究的目的:
- 在厌恶耐性酒精摄入期间,研究皮质otropin释放激素 (Crh) 系统中的性别差异.
- 确定Crhr1在中间前额叶皮层 (mPFC) 在厌恶抵抗中的作用.
主要方法:
- 利用两瓶选择范式与氨酸伪造的酒精来模拟厌恶抵抗.
- 在脑组织中使用RT-qPCR和RNAscope in situ杂交量化量化Crh和Crhr1mRNA水平.
- 给mPFC注入了一种Crhr1抗剂,以评估其对酒精消费的影响.
主要成果:
- 雌性小鼠在饮用氨酸改性酒精后,在mPFC中表现出Crhr1mRNA表达的增加.
- RNAscope证实女性的背中中和腹中中枢PFC中较高的Crhr1-阳性细胞数量.
- 药理上阻断mPFC Crhr1显著降低了女性但不是男性的因造酒精摄入量.
结论:
- 在mPFC中的Crhr1系统与反感抗性酒精摄入有关,特别是在女性中.
- 这些发现突出了AUD中潜在的性别特异性机制,并建议Crhr1作为治疗点.
关键词:
酒精饮料 酒精饮料 酒精饮料 酒精饮料这种厌恶的厌恶.在CRH中,CRH就是CRH.人权宣言1 人权宣言1皮质激素释放激素的皮质激素.前额叶皮层前额叶皮层.性差异性差异性差异性差异性差异性差异性差更多相关视频
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