针对中枢神经系统淋巴瘤的CAR T细胞疗法
Caroline Houillier1, Sylvain Choquet2
1Neurooncology Department, Groupe Hospitalier Pitié-Salpêtrière, APHP, Sorbonne Université, Inserm, CNRS, UMR S 1127, ICM, IHU, Paris, France. caroline.houillier@aphp.fr.
Current oncology reports
|October 28, 2024
概括
化学抗原受体 (CAR) T细胞疗法显示了中枢神经系统 (CNS) 淋巴瘤的高响应率. 尽管存在神经毒性问题,但该疗法对中枢神经系统淋巴瘤具有可控的安全性,具有前景.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 抗CD19CAR T细胞疗法对全身扩散大B细胞淋巴瘤有效.
- 以前,由于对神经毒性的担忧,中枢神经系统 (CNS) 淋巴瘤被排除在试验之外.
研究的目的:
- 评估CAR T细胞治疗中枢神经系统淋巴瘤的疗效和安全性.
- 审查最近关于CAR T细胞治疗初级和二级中枢神经系统淋巴瘤的研究.
主要方法:
- 对中枢神经系统淋巴瘤的CAR-T细胞治疗发表的研究进行系统审查.
- 分析反应率,无进展生存 (PFS) 和神经毒性.
主要成果:
- 在重度预先治疗的中枢神经系统淋巴瘤患者中观察到高响应率 (32-67%的完整响应).
- 在多项研究中报告的一年PFS率为40-60%.
- 神经毒性发生在36-68%的患者中,重度 (3-4级) 神经毒性发生在4.5-29%的患者中.
结论:
- 卡尔T细胞疗法在中枢神经系统淋巴瘤中显示出有前途的疗效,与全身淋巴瘤相似.
- 观察到的毒性概况,包括神经毒性,是可以管理的,并支持中枢神经系统淋巴瘤的进一步发展.
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