一个横截面研究血液金属混合物暴露和高尿素血症之间的联系
Jierui Wang1,2, Weixuan Wang3, Liufu Cui2
1School of Public Health, North China University of Science and Technology, 21 Bohai Road, Cao Fei Dian, Tangshan, 063210, Hebei, China.
血液中的金属混合物,特别是铁 (Fe), (Pb) 和 (Zn),与中国成年人患高尿血症 (HUA) 的风险增加有关. 这些发现凸显了环境暴露对代谢健康的潜在影响.
科学领域:
- 环境健康 环境健康
- 代谢性疾病流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 高尿路血 (HUA) 是痛风和其他代谢障碍的重要危险因素.
- 环境金属暴露在HUA发展中的作用尚未完全理解.
- 了解这些关联对于公共卫生干预至关重要.
研究的目的:
- 为了研究血液金属混合物与中国成年人群中高尿血症 (HUA) 风险之间的关联.
- 识别导致HUA风险的特定金属及其组合效应.
主要方法:
- 采用中国凯卢安队列试验数据的横截面研究.
- 血液中的金属度 (Fe,Pb,Ca,Cu,Mg,Zn,Se,Mn) 通过诱导合血质谱法测量.
- 多变量逻辑回归和加权定量总和 (WQS) 回归模型用于统计分析.
主要成果:
- 总共有3706名参与者被纳入,其中12.52%被诊断为HUA.
- 血中 (Pb),铁 (Fe), (Ca), (Mg) 和 (Zn) 的升高水平与HUA风险的增加显著相关.
- WQS回归发现金属混合物和HUA之间存在积极的关联,其中Fe,Mg,Pb和Zn是主要贡献者. 这些金属在多金属模型中仍然很重要.
结论:
- 同时暴露于包括Fe,Pb,Ca,Cu,Zn,Mg,Se和Mn在内的金属混合物,与中国成年人的HUA风险增加有关.
- (Pb),铁 (Fe) 和 (Zn) 显示对HUA风险的影响最大.
- 这种联系在年轻成年人 (<60岁),女性,超重个体,非吸烟者和饮酒者中更为明显,表明了显著的相互作用效应.
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