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Updated: Jun 9, 2025

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
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An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis

Published on: November 22, 2024

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对基tRNA模仿固态相合成的通用支持

Julia Thaler1, Christoph Mitteregger1, Laurin Flemmich1

  • 1Institute of Organic Chemistry, Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.

Chembiochem : a European journal of chemical biology
|October 28, 2024
PubMed
概括

研究人员开发了一种通用固体支,用于合成RNA-联体,其模仿基转移RNA (tRNA). 这种新方法简化了用于研究蛋白质合成的多种-RNA结构的创建.

关键词:
生物有机化学 生物有机化学核化物是一种核化物.可光解裂的固体支.配合RNA酸的配合物固相合成的固相合成方法

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Transfer RNA Synthesis02:36

Transfer RNA Synthesis

One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
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