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铁离子交联的氨酸珠子:药物输送使用的潜力
Hadeia Mashaqbeh1, Rana Obaidat2, Meriem Rezigue1
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Drug development and industrial pharmacy
|October 28, 2024
概括
这项研究开发了使用铁离子增强机械性能的pH敏感氨酸 (HA) 珠. 这些HA珠显示出作为口服药物递送系统的潜力,提供延长释放的甲胺.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 氨酸 (HA) 具有有吸引力的特性,但将其制成珠子仍然具有挑战性.
- 开发强大的和功能性的基于HA的交付系统对于各种应用至关重要.
研究的目的:
- 使用铁离子制备pH敏感的氨酸 (HA) 凝珠.
- 为了研究这些HA珠的潜力,作为水友药物的口服药物输送系统.
- 评估交联密度和HA度对药物释放和胀行为的影响.
主要方法:
- 使用铁离子制备HA珠子的离子凝.
- 通过FTIR,DSC和SEM进行表征.
- 在不同pH条件下对甲福明的捕获,释放动力学和胀的体外评估.
主要成果:
- 实现了甲胺的高捕获效率 (79.56%).
- FTIR证实了铁离子和HA之间的离子相互作用,没有显著的药物-聚合物相互作用.
- SEM和DSC表明成功地将甲胺纳入药物.
- 甲胺的pH依赖延长释放,遵循第一阶动力学.
结论:
- 通过铁离子交联成功制备了具有增强机械性能的pH敏感HA凝珠.
- 证明了这些HA珠的潜力,作为一个可行的口服药物输送系统.
- 该配方为潜在的生物医学应用提供了增值的方法.
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