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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Updated: Jun 9, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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在2至16周的健康小猫中进行甲状腺功能测试.

Christina L Marino1, Timothy A Bolton2, Margret L Casal1

  • 1Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Journal of feline medicine and surgery
|October 28, 2024
PubMed
概括

小猫的甲状腺激素水平在5-6周左右达到峰值. 了解这些正常度对于诊断色小猫的先天性甲状腺功能低下症至关重要.

关键词:
甲状腺功能低下症 甲状腺功能低下症这是先天的,先天的.色的小猫子综合征 色的小猫子综合征新生儿新生儿新生儿新生儿儿科 儿科 儿科甲状腺素 甲状腺素

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科学领域:

  • 兽医医学 兽医医学 兽医医学
  • 内分泌学 在内分泌学.
  • 新生儿动物卫生新生儿动物卫生

背景情况:

  • 关于健康小猫正常甲状腺激素水平的数据有限.
  • 遗传性甲状腺功能低下症 (CH) 是色小猫综合征 (FKS) 的潜在原因.

研究的目的:

  • 在2至16周的健康小猫中确定正常的血清甲状腺激素度 (TT4,ft4,TT3,ft3,TSH).
  • 确定新生儿和儿科猫的特定年龄的参考范围.
  • 提供数据,以帮助诊断患有FKS的小猫中CH.

主要方法:

  • 从19只年龄在2-16周的健康小猫收集了血清样本.
  • 测量了总甲状腺素 (TT4),自由甲状腺素 (fT4),总三甲状腺素 (TT3),自由三甲状腺素 (fT3) 和甲状腺刺激激素 (TSH) 的度.
  • 对不同年龄组的结果进行了分析.

主要成果:

  • 甲状腺激素度 (TT4,FT4,TT3,FT3) 与年龄有显著的变化.
  • 峰值TT4和ft4水平分别发生在6周和5周,TT4超过成人参考间隔超过50%的样本在6周.
  • 在所有年龄组中,TSH水平保持稳定,处于成年猫参考区间 (ACRI) 之内.

结论:

  • 小猫甲状腺激素水平在5-6周左右自然达到峰值,这可能是由于断奶后的激素变化和发育.
  • 建立这些正常范围对于兽医来说至关重要,以区分CH与其他导致FKS的原因.
  • 这项研究为猫类儿科内分泌学提供了重要的参考数据.