经切除术治疗的细胞癌患者随着时间的推移而改善的生存率:一项纵向倾向性得分匹配研究
Kenjiro Kishitani1, Satoru Taguchi1, Koji Tanaka1
1Department of Urology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
概括
最近 (2000 - 2018) 接受细胞癌 (RCC) 手术的患者与早期 (1981 - 1999) 接受治疗的患者相比,经历了显著改善的生存结果. 这种改善可能与越来越多地采用微创手术技术有关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术瘤学手术瘤学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 在过去的三十年中,细胞癌 (RCC) 治疗发生了显著的进化.
- 在接受切除术的RCC患者中,关于时间生存趋势的现实数据有限.
研究的目的:
- 为了评估细胞癌 (RCC) 患者的存活率改善,在不同手术时代接受了切除术.
- 使用倾向分数匹配 (PSM) 分析纵向队列数据,以比较早期和最近的外科手术期间的结果.
主要方法:
- 对960名经过彻底或部分切除术 (1981-2018) 的RCC患者进行了回顾性审查.
- 患者被分为两组:1981-1999年 (早期时代) 和2000-2018年 (最近的时代).
- 倾向性得分匹配 (PSM) 用于比较整体存活率 (OS),癌症特定存活率 (CSS) 和无复发存活率 (RFS).
主要成果:
- 通过使用PSM获得466名患者 (233名每期) 的匹配队列.
- 最近的时代与早期的时代相比 (全部是开放式手术) 发生了向最小侵入性手术 (47.4%) 的转变.
- 最近的时代队列与早期的时代队列相比,显示了显著更长的OS,CSS和RFS.
结论:
- 在近期 (2000 - 2018) 接受RCC治疗的患者与早期 (1981 - 1999) 相比,表现出更高的生存率.
- 越来越多地采用微创手术方法 (镜/机器人) 是导致RCC治疗中观察到的生存率改善的一个潜在因素.
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