从有意自我伤害的患者血液的定性分析:处方药和检测药物之间的差异
Masato Masuda1, Brian Waters2, Leo Gotoh1,3
1Department of Psychiatry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Neuropsychopharmacology reports
|October 28, 2024
概括
在故意自伤 (DSH) 病例中,血液检查显示76%的患者服用非处方药 (NPD). 这突显了DSH患者处方药和实际药物使用之间的显著差距.
科学领域:
- 法医毒理学 法医毒理学
- 精神病学是一个精神病学.
- 临床化学 临床化学
背景情况:
- 蓄意自我伤害 (DSH) 通常涉及药物摄入,但缺乏关于DSH患者血液中发现的特定药物的数据.
- 之前的研究还没有系统地分析和比较在DSH病例中血中药物水平与处方药的水平.
研究的目的:
- 为了分析患者的血液中存在的药物,这些患者有意自伤 (DSH).
- 将检测到的药物与患者处方药物进行比较,并确定非处方药 (NPD) 使用.
主要方法:
- 从2021年4月至2022年9月期间入院福冈大学医院的55名DSH患者收集了血液样本.
- 评估了精神病史和最近的DSH方法,以及对前一个月内处方药物的审查.
- 液体染色学-双重质谱法 (LC-MS/MS) 用于血液药物分析,参与者按精神药物处方状态分组.
主要成果:
- 在76% (55人中42人) 的DSH患者中检测到非处方药 (NPD).
- 在服用药物或非处方药 (OTC) 药物过量患者中,NPD检测显着更高 (p=0.036).
- 在使用其他DSH方法的患者和没有任何处方药的患者中也发现了NPD.
结论:
- 这项研究是首次关注DSH患者的综合血液药物分析.
- 处方药和检测到的药物之间存在很大的差异,大约80%的患者服用了NPD.
- 这些发现强调了DSH中非处方药使用的普遍性以及改善监测和干预的必要性.
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