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Updated: Jun 9, 2025

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

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蛋白质语言模型学习相互作用的序列动图的进化统计

Zhidian Zhang1,2,3, Hannah K Wayment-Steele4,5, Garyk Brixi6

  • 1Harvard University, Cambridge, MA 02138.

Proceedings of the National Academy of Sciences of the United States of America
|October 28, 2024
PubMed
概括

像ESM-2这样的蛋白质语言模型 (pLM) 存储共同进化的残留统计数据,类似于旧的方法. 他们使用局部序列动图预测蛋白质接触,揭示了他们生物物理理解的局限性.

关键词:
解释性研究是解释性研究.语言模型语言模型蛋白质结构预测 蛋白质结构预测

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