一个综合平台,用于调查药物与微生物相互作用,以支持药物微生物组学研究
Yu-Hsien Tai1, Cheng-Yen Kao2, Ya-Ping Zhang1
1Department of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Talanta
|October 28, 2024
概括
这项研究引入了研究药物微生物相互作用的新平台,揭示了Lactiplantibacillus pentosus如何生物转化迪戈辛. 这推动了药物微生物组学研究,揭示了新型微生物对药物代谢的影响.
科学领域:
- 药理学和微生物学 药理学和微生物学
- 药物代谢和微生物群相互作用
背景情况:
- 人类微生物组显著影响药物的疗效,生物可用性和毒性.
- 了解药物-微生物相互作用对于推进药物微生物组学至关重要.
- 之前的研究已经确定了微生物在药物生物积累,生物转化和生长调节中的作用.
研究的目的:
- 为研究药物与微生物相互作用提供一个综合平台.
- 专注于生物转化,生物积累,代谢学,外代谢学,脂质学和外脂质学.
- 为了说明平台的可行性,使用狄戈辛和乳植物菌 pentosus.
主要方法:
- 开发一个用于药物与微生物相互作用分析的综合平台.
- 代谢学,外代谢学,脂质学和外脂质学的应用.
- 使用液体染色学-质谱学量化狄戈辛生物转化和生物积累的量化.
主要成果:
- 乳菌的生长没有受到狄戈辛的影响.
- 迪戈辛对L. pentosus.中的细胞内和细胞外代谢物和脂质产生了影响.
- 大约8.7%的狄戈辛被L. pentosus生物转化,而狄戈西基宁被确定.
结论:
- 综合平台成功地揭示了狄戈辛与L. pentosus之间的新型相互作用.
- L. pentosus 可以显著影响狄戈辛的新陈代谢.
- 这项工作强调了在药理学研究和药物开发中考虑微生物代谢的重要性.
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