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在加拿大两个最大城市的空气中超细颗粒度和脑癌发病率

Marshall Lloyd¹, Toyib Olaniyan², Arman Ganji³

¹McGill University, Montreal, Canada.

Environment international

|October 28, 2024

概括

长期暴露于户外超细颗粒 (UFPs) 与患恶性脑瘤的风险更高有关. 这项研究表明,UFPs可能在脑癌的发展中发挥作用.

科学领域:

环境流行病学环境流行病学
毒理学毒理学毒理学
在瘤学瘤学.

背景情况:

恶性脑瘤的存活率很低,确定的风险因素很少.
室外超细颗粒 (UFPs) 小于100纳米,可能进入大脑并促进瘤生长.
目前对UFP和脑瘤的流行病学数据有限.

研究的目的:

调查长期暴露于户外超细颗粒 (UFP) 与恶性脑瘤发生率之间的关联.
量化与不同程度的UFP暴露相关的大脑瘤风险.

主要方法:

利用与蒙特利尔和多伦多 (2001-2015) 150万个人的住宅地点相关的高分辨率户外UFP度和尺寸数据.
采用Cox比例危险模型来评估UFP与恶性脑瘤发病率的关联.
调整以考虑混因素,包括其他室外空气污染物.

主要成果:

总共记录了1365起脑瘤事件.
在长期暴露于UFP和脑瘤发病率之间发现了一致的积极关联.
增加的风险在10.5%至15.3%之间,每增加10,000颗颗粒/cm3的室外UFP;对于氧化气体,黑碳或PM2.5.5没有观察到任何显著的关联.

结论:

长期暴露于户外UFP与患恶性脑瘤的风险增加有关.
这种风险意味着每年在大约24个额外的脑瘤病例中,在一个拥有300万人口的城市中,每增加1万颗粒子/厘米3的UFP增加3个.

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