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身体质量指数从出生到成年早期的轨迹和肺功能发展轨迹

Gang Wang^1,2,3,4, Jenny Hallberg^2,5, Simon Kebede Merid²

¹Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China gang.wang@ki.se.

The European respiratory journal

|October 28, 2024

概括

从童年开始保持正常的体重指数 (BMI) 对长期的肺部健康至关重要. 研究表明,BMI的轨迹在整个青春期和成年期显著影响肺功能发展.

科学领域:

儿科肺病学儿科肺病学
增长和发展研究研究.
肥胖研究的研究.

背景情况:

关于身体质量指数 (BMI) 在童年和青春期的轨迹如何影响肺功能,目前的研究有限.
了解这些长期影响对于制定有效的公共卫生战略至关重要.

研究的目的:

研究从出生到24岁的不同体重指数 (BMI) z-score轨迹和24岁的肺功能之间的关联.
为了确定与肺功能发育受损相关的特定BMI模式.

主要方法:

瑞典BAMSE出生队列的前性研究 (n=3204).
隐性类混合建模以确定BMI z-score轨迹.
螺旋计 (支气管扩展前和后) 和肺清除指数 (LCI) 在24岁时测量.
在24岁时分析的尿道代谢量.

主要成果:

确定了六个不同的BMI轨迹组.
加快的BMI增加与FEV1/FVC比率降低和LCI升高有关.
持续高的BMI与较低的FEV1/FVC增长和增加的LCI有关.
持续的低BMI与FEV1/FVC降低和肺功能增长受损有关.
与FEV1测量相关的histidine代谢物.

结论:

儿童BMI轨迹显著影响到成年期的肺功能发展.
在儿童时期促进正常BMI的干预措施可能会改善长期的肺部健康.
特定的BMI模式,如加速增加或持续高水平,对肺功能有害.

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