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Updated: Jun 11, 2026

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纠正:艾滋病毒病毒被抑制的人群中的微质细胞的基因表达和染色质构造

Johannes Cm Schlachetzki1,2, Sara Gianella3, Zhengyu Ouyang4

  • 1Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA jschlachetzki@ucsd.edu.

Life science alliance
|October 28, 2024
PubMed
概括

即使使用抗逆转录病毒疗法 (ART),微质细胞也可以容纳HIVRNA和DNA. 这表明,尽管接受了治疗,但大脑中的病毒储存库仍然存在.

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Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...