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梅丽莎 officinalis 通过MAPK和Nrf2信号调节脂聚糖诱导的BV2微细胞激活

Ji-Won Choi¹, Sang Yoon Choi¹, Guijae Yoo¹

¹Korea Food Research Institute, Wanju-Gun, Jeollabuk-do 55365, Republic of Korea.

Journal of microbiology and biotechnology

|October 28, 2024

概括

梅丽莎官员素提取物通过抑制微质激活和增强抗氧化防御来减少神经炎症. 这表明神经退行性疾病 (如阿尔茨海默氏症和帕金森症) 的潜在治疗益处.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
免疫学免疫学免疫学

背景情况:

神经炎症和微质激活是神经退行性疾病的关键因素.
向微质激活可能提供一种减缓疾病进展的策略.

研究的目的:

为了研究梅丽莎官员植物乙醇提取物对脂聚糖 (LPS) 诱导的微质激活的作用.
阐明作用的潜在机制,包括炎症和抗氧化途径.

主要方法:

BV2微质细胞被用LPS和梅丽莎官网植物提取物治疗.
试验包括MTT的生命力,格瑞斯试剂的氧化 (NO),细胞因子的qPCR,以及西斑/免疫光信号通路 (MAPK,TLR4,NF-κB) 和抗氧化剂标志物 (Nrf2,HO-1,catalase,SOD2).
高性能液体染色学 (HPLC) 量化罗斯马林酸含量.

主要成果:

梅丽莎官员取物显著抑制了LPS诱导的NO生产,并减少了炎症性细胞因子表达.
提取物降低了关键的炎症媒介 (iNOS,COX-2,TLR4,NF-κB,MAPK通路) 的调节,并提高了抗氧化剂标志物 (Nrf2,HO-1,catalase,SOD2).

结论:

梅丽莎官员植物乙醇提取物通过调节神经炎症和增强抗氧化能力来显示神经保护性质.
这些发现突出了其作为治疗神经退行性疾病与炎症相关的治疗剂的潜力.

关键词:

在BV2微质上梅丽莎·奥菲西纳利斯 (Melissa officinalis) 是一个公务员.Nrf2 没有任何问题.在 TLR4 中,神经退行性疾病是一种神经退行性疾病.神经炎症是一种神经炎症.

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