运动改善肌肉线粒体功能障碍相关的脂质特征在昼夜节律干扰下
Yu Gu1, Dong-Hun Seong1, Wenduo Liu1
1Department of Sports Science, College of Natural Science, Jeonbuk National University, Jeonju 54896, Korea.
概括
耐力运动训练 (EXT) 可以抵消轮班工作引起的昼夜节律 (CR) 障碍. EXT改善了骨肌肉的线粒体功能和抗氧化能力,可能降低心血管疾病的风险.
科学领域:
- 运动生理学 运动生理学
- 时间生物学 时间生物学
- 分子生物学分子生物学
背景情况:
- 轮班工作破坏昼夜节律 (CR),导致健康风险,如失脂症.
- 骨肌肉 (SKM) 线粒体功能障碍和氧化应激与CR障碍有关.
- 耐力运动训练 (EXT) 对CR相关问题的治疗潜力尚未完全理解.
研究的目的:
- 调查EXT是否可以改善骨肌肉中CR诱导的风险因素.
- 为了检查EXT对线粒体生物发生,氧化应激和CR破坏的骨肌肉中亡的作用.
- 分析轮班工作对失脂症和心血管风险的影响.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 的数据和一种动物模型 (老鼠) 诱导了CR干扰.
- 在12周的CR干扰后,在8周内比较久坐和EXT组.
- 分析了骨肌肉组织的分子变化,包括线粒体生物发生,抗氧化剂水平和亡蛋白.
主要成果:
- 在SKM中,CR干扰增加了脂质失调,改变了时钟蛋白,提高了亡标志物,并减少了线粒体生物发生.
- EXT改善了LDL-C和HDL-C水平,并增强了SKM中的线粒体生物发生和抗氧化能力.
- EXT调节的亡蛋白表达,抵消CR干扰的负面影响.
结论:
- 轮班工作引起的CR障碍会对骨肌产生负面影响,导致脂质障碍和线粒体功能受损.
- 耐力运动训练 (EXT) 可以减轻CR干扰引起的脂质障碍和骨肌功能障碍.
- 作为一种治疗策略,EXT显示出降低轮班工人心血管疾病风险的潜力.
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